Lecture syllabus

Date

Lecture topic

Readings

Tu, 9/1

1.  Course introduction, water

Course information

Lecture syllabus

Ch. 2: 47-58

Th, 9/3

2.  Water, pH & buffers

Problem set 1:  pH and buffers (due 9/10)

Ch. 2: 58-69

Tu, 9/8

3.  Amino acids: structure & chemistry

Ch. 3:75-89

Th, 9/10

4. The peptide bond & covalent structure of proteins

Problem set 2:  amino acids (due 9/18)

Ch.4:115-143

Tu, 9/15

5.  Thermodynamics & kinetics of protein folding

Ch. 4:143-151

Th, 9/17

6. Protein structure & function: myoglobin & hemoglobin I

Ch. 5:157-174

Tu, 9/22

7. Protein structure & function: myoglobin & hemoglobin II

Problem set 3:  hemoglobin (due 9/30)

Ch. 5:157-174

Th, 9/24

8. Paper 1 – A silent polymorphism in the MDR1 gene changes substrate specificity

Posted on Moodle

Tu, 9/29

9. Protein function:  enzymes

Ch. 6:189-200; 214-218

Th, 10/1

10. Enzyme kinetics

Exam 1 (classes 1-8) - available at Collier Library from noon Th, 10/1 through noon W, 10/7

Ch. 6:200-213

Tu, 10/6

11. Regulation of enzyme activity

Problem set 4: enzyme kinetics (due 10/20)

Ch. 6:226-236

Th, 10/8

12. Carbohydrate biochemistry

Ch. 7:243-269

Tu, 10/13

Th, 10/15

FALL BREAK

Tu, 10/20

13. Lipid biochemistry

Problem set 5:  carbs & lipids (due 10/27)

Ch. 10:357-370

Th, 10/22

14. Biological membranes

Ch. 11:385-402

Tu, 10/27

15. Membrane transport

Ch. 11:402-427

Th, 10/29

16. Paper 2 – Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens

Posted on Moodle

Tu, 11/3

17. Introduction to metabolism

Intro II, p. 501-504

Th, 11/5

18.  Bioenergetics and thermodynamics

Exam 2 (classes 9-16) - available at Collier Library from noon Th, 11/5 through noon W, 11/11

Ch. 13:505-527

Tu, 11/10

19. Glycolysis & glycogen metabolism

Ch. 14:543-568

Ch. 15:612-620

Th, 11/12

20. Citric acid cycle

Problem set 6:  metabolism I (due 11/17)

Ch. 16:633-656

Tu, 11/17

21. Fatty acid oxidation

Problem set 7:  metabolism II (due 11/24)

Ch. 17:667-688

Th, 11/19

22. Redox reactions & electron transport chain

 Ch. 13:528-537

Ch. 19:731-747

Tu, 11/24

23. Oxidative phosphorylation

Problem set 8:  thermodynamics/redox reactions (due 12/1)

 Ch. 19:747-759

Th, 11/26

THANKSGIVING

Tu, 12/1

24. Hormonal regulation of metabolism I

Ch. 15:601-606; 620-626;

Ch. 23:951-960

Th, 12/3

25. Hormonal regulation of metabolism II

Ch. 15:601-606; 620-626;

Ch. 23:951-960

Tu, 12/8

26. Paper 3- Superoxide activates mitochondrial uncoupling proteins

Posted on Moodle

Th, 12/10

27. Wrap up and review

Self-scheduled final exam (classes 17-27) – College deadline December 18, 12:30 p.m.