Modern Medicinal Chemistry - bmc.CHEM.B515.001.F26
Section outline
-
A survey of topics related to drug discovery including lead discovery, target interactions, structural optimization, drug metabolism and drug synthesis. The course will engage in an advanced treatment of these topics with particular attention to an understanding of drug design and development on the molecular level. Case studies will be used to illustrate the application of these principles.
-
This will likely transform your life into a paradise of drug-induced good health.
-updated 9-1-26
281.6 KB · Uploaded 09/1/26, 17:36 -
You should have familiarity with these topics and therefore I will assume that I don't need to elaborate on these subjects when we encounter them.
I suspect most of you've had very little coverage of heteroaromatics, which are a common component of many small molecule drugs, so I will likely provide some background early in the course.
786.5 KB · Uploaded 08/25/26, 16:56 -
If you'd like to meet with Dr. Mal for a 1-on-1 (or 1-on-X with fellow PB's in your study group), please follow the Calendly link to schedule a meeting time in Park 270, Dr. Mal's office. The appointments are for 20 minutes.
-
This may or may not be useful for your studies of the medicinal chemistry literature. A lot of it deals with drug metabolism issues, which are extremely important, and will be discussed in the first few weeks of lectures.
3.9 MB · Uploaded 08/25/26, 16:56
-
-
-the recording aborted early
143.8 MB · Uploaded 08/31/26, 14:59 -
-skeleton notes to be completed in class presentation
696.8 KB · Uploaded 08/25/26, 16:56 -
lecture notes from Mon. 8-31 and Wed. 9-2.
Note: The screenshot recording of the lecture on Wed. 9-2-26 had no audio, so there is no recording. Sorry!
3.7 MB · Uploaded 09/6/26, 11:34 -
screen shot recording of intro to medicinal chemistry
-the review of ephedrine, pseudoephedrine, and related phenethylamines (pharmacophores)
-introduction to Med Chem approaches, including rational drug design and high throughput screening (HTS)
889.5 MB · Uploaded 08/31/26, 15:16
-
-
-
Dean G. Brown and Jonas Bostrom, J. Med. Chem. 2018, 61, 21, 9442–9468.
8.0 MB · Uploaded 08/25/26, 16:56 -
-We will start this lecture notes packet on Wednesday, Sept. 9
697.4 KB · Uploaded 08/25/26, 16:56 -
-annotated lecture notes based on Where Do Recent Small Molecule Clinical Development Candidates Come From? | Journal of Medicinal Chemistry
-a discussion of lead compound discovery and development
-Wed. Sept. 9
2.6 MB · Uploaded 09/9/26, 14:17 -
lecture on drug lead development and where do new drugs come from today
565.9 MB · Uploaded 09/9/26, 14:21 -
Opened: Monday, August 31, 2026, 11:00 PMDue: Tuesday, September 8, 2026, 11:00 PM
Submitted through course portal or under my office door by 11 PM on Tuesday.
-
-
-
-
Opened: Wednesday, September 9, 2026, 12:00 AMDue: Monday, September 14, 2026, 11:40 AM
Due by the start of class, 11:40 AM Monday, September 14, 2026
-
These lecture notes will be started on Monday, Sept. 14.
528.9 KB · Uploaded 08/25/26, 16:56 -
Likely starting on Wed. Sept. 16.
767.6 KB · Uploaded 08/25/26, 16:56
-
-
-
-Likely starting on Tues. Feb. 11
622.9 KB · Uploaded 08/25/26, 16:56 -
COVID protease inhibitor drug by Pfizer
-lecture will start on Thurs. Feb. 13
1.1 MB · Uploaded 08/25/26, 16:56
-
-
-
-
604.1 KB · Uploaded 08/25/26, 16:56
-
-
-
-
TBA
-
-
-
class ave.=123.55/150 (82%)
updated 5/2/25
1.2 MB · Uploaded 08/25/26, 16:56 -
5/2/25: 2025 Final exam guidelines updated with the material for the last four presentations.
224.6 KB · Uploaded 08/25/26, 16:56 -
-
-