In response to Mumford, primarily:
If a city is indeed comparable to a body, how does a body integrate parts of its environment into itself? What processes does a body initiate to encounter and accept new information from outside? What can we learn about city design, social adaptation, and immigration from human body's response to new environments? (Microbes entering skin, stomach, mouth; minerals, pollutants, allergens in dust and air entering lungs and bloodstream; differences in local water and plant life; sun and climate intensity)
Furthermore, how does the body feed its host (in this case, the environment and ecosystem we live within)? How are discarded cells returned to the ecosystem?